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The Anthracycline Metabolite Doxorubicinol Abolishes RyR2 Sensitivity to Physiological Changes in Luminal Ca2+ through an Interaction with Calsequestrin.
Hanna, Amy D; Lam, Alexander; Thekkedam, Chris; Willemse, Hermia; Dulhunty, Angela F; Beard, Nicole A.
Affiliation
  • Hanna AD; John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia (A.D.H., A.L., C.T., A.F.D.) and Health Research Institute, Faculty of Education, Science, Technology and Maths, University of Canberra, Australian Capital Territory, Canberra, A
  • Lam A; John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia (A.D.H., A.L., C.T., A.F.D.) and Health Research Institute, Faculty of Education, Science, Technology and Maths, University of Canberra, Australian Capital Territory, Canberra, A
  • Thekkedam C; John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia (A.D.H., A.L., C.T., A.F.D.) and Health Research Institute, Faculty of Education, Science, Technology and Maths, University of Canberra, Australian Capital Territory, Canberra, A
  • Willemse H; John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia (A.D.H., A.L., C.T., A.F.D.) and Health Research Institute, Faculty of Education, Science, Technology and Maths, University of Canberra, Australian Capital Territory, Canberra, A
  • Dulhunty AF; John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia (A.D.H., A.L., C.T., A.F.D.) and Health Research Institute, Faculty of Education, Science, Technology and Maths, University of Canberra, Australian Capital Territory, Canberra, A
  • Beard NA; John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia (A.D.H., A.L., C.T., A.F.D.) and Health Research Institute, Faculty of Education, Science, Technology and Maths, University of Canberra, Australian Capital Territory, Canberra, A
Mol Pharmacol ; 92(5): 576-587, 2017 11.
Article in En | MEDLINE | ID: mdl-28916620
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Full text: 1 Database: MEDLINE Main subject: Calsequestrin / Doxorubicin / Calcium / Anthracyclines / Ryanodine Receptor Calcium Release Channel / Myocytes, Cardiac Type of study: Diagnostic_studies Limits: Animals Language: En Year: 2017 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Calsequestrin / Doxorubicin / Calcium / Anthracyclines / Ryanodine Receptor Calcium Release Channel / Myocytes, Cardiac Type of study: Diagnostic_studies Limits: Animals Language: En Year: 2017 Type: Article