Driving Rel-iant Tregs toward an Identity Crisis.
Immunity
; 47(3): 391-393, 2017 09 19.
Article
in En
| MEDLINE
| ID: mdl-28930651
ABSTRACT
Inhibiting Treg cell function in tumors is an attractive strategy to improve anti-cancer immunity. In a pair of papers in Immunity and Cell, Ghosh and colleagues show that the canonical NF-κB subunits p65 and c-Rel have non-redundant, critical roles in promoting Treg cell development and function (Oh et al., 2017). Targeting c-Rel blunts Treg cell immunosuppressive activity in the tumor microenvironment and enhances anti-tumor T cell responses (Grinberg-Bleyer et al., 2017).
Full text:
1
Database:
MEDLINE
Main subject:
NF-kappa B
/
Proto-Oncogene Proteins c-rel
Limits:
Humans
Language:
En
Year:
2017
Type:
Article