Role of Alanine Racemase Mutations in Mycobacterium tuberculosis d-Cycloserine Resistance.
Antimicrob Agents Chemother
; 61(12)2017 12.
Article
in En
| MEDLINE
| ID: mdl-28971867
ABSTRACT
A screening of more than 1,500 drug-resistant strains of Mycobacterium tuberculosis revealed evolutionary patterns characteristic of positive selection for three alanine racemase (Alr) mutations. We investigated these mutations using molecular modeling, in vitro MIC testing, as well as direct measurements of enzymatic activity, which demonstrated that these mutations likely confer resistance to d-cycloserine.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Bacterial Proteins
/
Cycloserine
/
Drug Resistance, Bacterial
/
Alanine Racemase
/
Mutation
/
Mycobacterium tuberculosis
Type of study:
Prognostic_studies
Language:
En
Year:
2017
Type:
Article