Sodium fluoride PET imaging as a quantitative pharmacodynamic biomarker for bone homeostasis during anti-DKK1 therapy for multiple myeloma.

Wang, Y; Yee, A J; Sirard, C; Landau, S; Raje, N; Mahmood, U

Wang, Y; Yee, A J; Sirard, C; Landau, S; Raje, N; Mahmood, U.

Affiliation

Wang Y; Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.
Yee AJ; Harvard Medical School, Boston, MA, USA.
Sirard C; Harvard Medical School, Boston, MA, USA.
Landau S; Center for Multiple Myeloma, Massachusetts General Hospital Cancer Center, Boston, MA, USA.
Raje N; Leap Therapeutics, Inc., Cambridge, MA, USA.
Mahmood U; Leap Therapeutics, Inc., Cambridge, MA, USA.

Blood Cancer J ; 7(10): e615, 2017 10 06.

Article in En | MEDLINE | ID: mdl-28984867

Subject(s)

Bone and Bones/pathology; Intercellular Signaling Peptides and Proteins/therapeutic use; Multiple Myeloma/complications; Positron-Emission Tomography/methods; Sodium Fluoride/chemistry; Aged; Aged, 80 and over; Biomarkers; Female; Homeostasis; Humans; Intercellular Signaling Peptides and Proteins/pharmacology; Male; Middle Aged; Multiple Myeloma/diagnostic imaging; Multiple Myeloma/drug therapy

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Full text: 1 Database: MEDLINE Main subject: Sodium Fluoride / Bone and Bones / Intercellular Signaling Peptides and Proteins / Positron-Emission Tomography / Multiple Myeloma Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Year: 2017 Type: Article

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