Polycyclic Polyprenylated Acylphloroglucinols: An Emerging Class of Non-Peptide-Based MRSA- and VRE-Active Antibiotics.
Angew Chem Int Ed Engl
; 56(50): 15852-15856, 2017 12 11.
Article
in En
| MEDLINE
| ID: mdl-28985019
ABSTRACT
In the past 20 years, peptide-based antibiotics, such as vancomycin, teicoplanin, and daptomycin, have often been considered as second-line antibiotics. However, in recent years, an increasing number of reports on vancomycin resistance in pathogens appeared, which forces researchers to find novel lead structures for potent new antibiotics. Herein, we report the total synthesis of a defined endo-typeâ
B PPAP library and their antibiotic activity against multiresistant S.â
aureus and various vancomycin-resistant Enterococci. Four new compounds that combine high activities and low cytotoxicity were identified, indicating that the PPAP core might become a new non-peptide-based lead structure in antibiotic research.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Phloroglucinol
/
Polycyclic Compounds
/
Methicillin-Resistant Staphylococcus aureus
/
Vancomycin-Resistant Enterococci
/
Anti-Bacterial Agents
Language:
En
Year:
2017
Type:
Article