Ex vivo feasibility study of endoscopic intraductal laser ablation of the breast.
Lasers Surg Med
; 50(2): 137-142, 2018 02.
Article
in En
| MEDLINE
| ID: mdl-28990682
ABSTRACT
OBJECTIVE:
To determine the feasibility and safety of breast endoscopic thulium laser ablation for treatment of intraductal neoplasia. STUDYDESIGN:
Ductoscopy is a minimally invasive endoscopic approach of the milk ducts of the breast via the nipple. Besides diagnosis in women with pathologic nipple discharge (PND), it allows non-invasive removal of intraductal lesions with a stalk like papillomas. Removal, however, is often incomplete and flat lesions cannot be targeted. We therefore developed laser ductoscopy.METHODS:
Dosimetry of laser ductoscopy was assessed in thirteen mastectomy specimens, applying power settings of 1-5 W with 100-1000 ms pulsed exposure to a 375-µm outer diameter thulium fiber laser. Subsequently histology was obtained from the breast tissue that was treated with the Thulium laser.RESULTS:
Endoscopic view was maintained during ductoscopic laser ablation at 1-3 W. Increasing power to 4-5 W caused impaired vision due to shrinkage of the main duct around the ductoscope tip. Histology revealed localized ablation of the duct wall.CONCLUSION:
We show for the first time that laser ductoscopy is technically feasible. The Thulium laser enables a superficial intraductal ablation and is a useful tool for intraductal interventions. An in vivo prospective study is needed to further demonstrate its potential. Lasers Surg. Med. 50137-142, 2018. © 2017 Wiley Periodicals, Inc.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Breast
/
Endoscopy
/
Laser Therapy
/
Nipples
Type of study:
Observational_studies
Limits:
Female
/
Humans
Language:
En
Year:
2018
Type:
Article