Inhibition of MEK/ERK signalling pathway promotes erythroid differentiation and reduces HSCs engraftment in ex vivo expanded haematopoietic stem cells.

Zarrabi, Morteza; Afzal, Elaheh; Asghari, Mohammad Hossein; Mohammad, Monireh; Es, Hamidreza Aboulkheyr; Ebrahimi, Marzieh

Inhibition of MEK/ERK signalling pathway promotes erythroid differentiation and reduces HSCs engraftment in ex vivo expanded haematopoietic stem cells.

Zarrabi, Morteza; Afzal, Elaheh; Asghari, Mohammad Hossein; Mohammad, Monireh; Es, Hamidreza Aboulkheyr; Ebrahimi, Marzieh.

Affiliation

Zarrabi M; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Afzal E; Royan Stem Cell Technology Company, Cord Blood Bank, Tehran, Iran.
Asghari MH; Royan Stem Cell Technology Company, Cord Blood Bank, Tehran, Iran.
Mohammad M; Animal Core Facility, Reproductive Biomedicine Research Center, Royan Institute for Animal Biotechnology, ACECR, Tehran, Iran.
Es HA; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Ebrahimi M; Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

J Cell Mol Med ; 22(3): 1464-1474, 2018 03.

Article in En | MEDLINE | ID: mdl-28994199

Subject(s)

Benzamides/pharmacology; Diphenylamine/analogs & derivatives; Erythroid Cells/drug effects; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells/drug effects; MAP Kinase Signaling System/drug effects; Adaptor Proteins, Signal Transducing/genetics; Adaptor Proteins, Signal Transducing/immunology; Animals; Animals, Newborn; Antigens, CD/genetics; Antigens, CD/immunology; Cell Differentiation; Cell Proliferation; Cells, Cultured; Diphenylamine/pharmacology; Erythroid Cells/cytology; Erythroid Cells/immunology; Female; Fetal Blood/cytology; Fetal Blood/immunology; GATA2 Transcription Factor/genetics; GATA2 Transcription Factor/immunology; Gene Expression Regulation; Glycophorins/genetics; Glycophorins/immunology; Graft Survival; Hematopoietic Stem Cells/cytology; Hematopoietic Stem Cells/immunology; Humans; Immunophenotyping; LIM Domain Proteins/genetics; LIM Domain Proteins/immunology; Mice; Pregnancy; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/immunology; T-Cell Acute Lymphocytic Leukemia Protein 1/genetics; T-Cell Acute Lymphocytic Leukemia Protein 1/immunology; Transplantation, Heterologous

Key words

MEK/ERK pathway; erythroid differentiation; ex vivo expansion; haematopoietic stem cells (HSCs); human umbilical cord blood (hUCB)

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Full text: 1 Database: MEDLINE Main subject: Benzamides / Hematopoietic Stem Cells / Hematopoietic Stem Cell Transplantation / MAP Kinase Signaling System / Erythroid Cells / Diphenylamine Language: En Year: 2018 Type: Article

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