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Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.
Pera, Marta; Larrea, Delfina; Guardia-Laguarta, Cristina; Montesinos, Jorge; Velasco, Kevin R; Agrawal, Rishi R; Xu, Yimeng; Chan, Robin B; Di Paolo, Gilbert; Mehler, Mark F; Perumal, Geoffrey S; Macaluso, Frank P; Freyberg, Zachary Z; Acin-Perez, Rebeca; Enriquez, Jose Antonio; Schon, Eric A; Area-Gomez, Estela.
Affiliation
  • Pera M; Department of Neurology, Columbia University Medical Center, New York, NY, USA.
  • Larrea D; Department of Neurology, Columbia University Medical Center, New York, NY, USA.
  • Guardia-Laguarta C; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
  • Montesinos J; Department of Neurology, Columbia University Medical Center, New York, NY, USA.
  • Velasco KR; Department of Neurology, Columbia University Medical Center, New York, NY, USA.
  • Agrawal RR; Institute of Human Nutrition, Columbia University Medical Campus, New York, NY, USA.
  • Xu Y; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
  • Chan RB; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
  • Di Paolo G; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
  • Mehler MF; Departments of Neurology, Neuroscience, and Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Perumal GS; Analytical Imaging Facility, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Macaluso FP; Analytical Imaging Facility, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Freyberg ZZ; Departments of Psychiatry and Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Acin-Perez R; Cardiovascular Metabolism Program, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
  • Enriquez JA; Cardiovascular Metabolism Program, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain.
  • Schon EA; Department of Neurology, Columbia University Medical Center, New York, NY, USA.
  • Area-Gomez E; Department of Genetics and Development, Columbia University Medical Center, New York, NY, USA.
EMBO J ; 36(22): 3356-3371, 2017 11 15.
Article in En | MEDLINE | ID: mdl-29018038
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Full text: 1 Database: MEDLINE Main subject: Amyloid beta-Protein Precursor / Endoplasmic Reticulum / Alzheimer Disease / Intracellular Membranes / Mitochondria Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Year: 2017 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Amyloid beta-Protein Precursor / Endoplasmic Reticulum / Alzheimer Disease / Intracellular Membranes / Mitochondria Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Year: 2017 Type: Article