Combination of Androgen Deprivation Therapy and Salvage Radiotherapy versus Salvage Radiotherapy Alone for Recurrent Prostate Cancer after Radical Prostatectomy.
Urol Int
; 99(4): 406-413, 2017.
Article
in En
| MEDLINE
| ID: mdl-29020683
ABSTRACT
INTRODUCTION:
To assess the value of androgen deprivation therapy (ADT) on salvage radiotherapy (RT) in post-prostatectomy recurrent prostate cancer patients, we compared the oncologic outcomes between patients receiving RT + ADT and those receiving RT alone. MATERIALS ANDMETHODS:
We reviewed the records of patients diagnosed with prostate cancer between 1995 and 2011, including 93 patients who underwent salvage RT and 69 patients who underwent salvage RT + ADT. The ADT-free duration after withdrawal was calculated to verify testosterone recovery.RESULTS:
Presalvage prostate serum antigen (PSA) was the only significantly different characteristic between the 2 groups (p < 0.001). The ADT-free duration was greater than 6 months in >80% of patients. Presalvage PSA ≥0.6 ng/mL, pathologic stage ≥T3b, and RT + ADT were significantly associated with biochemical progression after salvage treatment. RT + ADT reduced biochemical progression in patients with seminal vesicle invasion or presalvage PSA ≥0.6 ng/mL (p = 0.001) compared to RT alone; biochemical progression-free probability was unchanged in seminal vesicle noninvasive prostate cancer patients with presalvage PSA <0.6 ng/mL (p = 0.541).CONCLUSIONS:
RT + ADT reduced the risk of biochemical progression after salvage treatment in patients with seminal vesicle invasion or presalvage PSA ≥0.6 ng/mL, but had no effect in patients with seminal vesicle noninvasive disease and presalvage PSA <0.6 ng/mL.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Prostatectomy
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Prostatic Neoplasms
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Salvage Therapy
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Antineoplastic Agents, Hormonal
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Chemoradiotherapy
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Androgen Antagonists
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Neoplasm Recurrence, Local
Type of study:
Etiology_studies
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Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
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Humans
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Male
/
Middle aged
Language:
En
Year:
2017
Type:
Article