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Cognition, quality-of-life, and symptom clusters in breast cancer: Using Bayesian networks to elucidate complex relationships.
Xu, Selene; Thompson, Wesley; Ancoli-Israel, Sonia; Liu, Lianqi; Palmer, Barton; Natarajan, Loki.
Affiliation
  • Xu S; Department of Mathematics, University of California, San Diego, CA, USA.
  • Thompson W; Department of Psychiatry, University of California, San Diego, CA, USA.
  • Ancoli-Israel S; Department of Psychiatry, University of California, San Diego, CA, USA.
  • Liu L; Department of Psychiatry, University of California, San Diego, CA, USA.
  • Palmer B; Department of Psychiatry, University of California, San Diego, CA, USA.
  • Natarajan L; Veterans Affairs, San Diego Health Care System, San Diego, CA, USA.
Psychooncology ; 27(3): 802-809, 2018 03.
Article in En | MEDLINE | ID: mdl-29055062
ABSTRACT

OBJECTIVE:

Breast cancer patients frequently complain of cognitive dysfunction during chemotherapy. Patients also report experiencing a cluster of sleep problems, fatigue, and depressive symptoms during chemotherapy. We aimed to understand the complex dynamic interrelationships of depression, fatigue, and sleep to ultimately elucidate their role in cognitive performance and quality of life amongst breast cancer survivors undergoing chemotherapy treatment.

METHODS:

Our study sample comprised 74 newly diagnosed stage I to III breast cancer patients scheduled to receive chemotherapy. An objective neuropsychological test battery and self-reported fatigue, mood, sleep quality, and quality of life were collected at 3 time points before the start of chemotherapy (baseline BL), at the end of cycle 4 chemotherapy (C4), and 1 year after the start of chemotherapy (Y1). We applied novel Bayesian network methods to investigate the role of sleep/fatigue/mood on cognition and quality of life prior to, during, and after chemotherapy.

RESULTS:

The fitted network exhibited strong direct and indirect links between symptoms, cognitive performance, and quality of life. The only symptom directly linked to cognitive performance was C4 sleep quality; at C4, fatigue was directly linked to sleep and thus indirectly influenced cognitive performance. Mood strongly influenced concurrent quality of life at C4 and Y1. Regression estimates indicated that worse sleep quality, fatigue, and mood were negatively associated with cognitive performance or quality of life.

CONCLUSIONS:

The Bayesian network identified local structure (eg, fatigue-mood-QoL or sleep-cognition) and possible intervention targets (eg, a sleep intervention to reduce cognitive complaints during chemotherapy).
Subject(s)
Key words

Full text: 1 Database: MEDLINE Main subject: Quality of Life / Sleep Wake Disorders / Breast Neoplasms / Cognitive Dysfunction / Cancer Survivors Type of study: Diagnostic_studies / Etiology_studies Limits: Adult / Female / Humans / Middle aged Language: En Year: 2018 Type: Article

Full text: 1 Database: MEDLINE Main subject: Quality of Life / Sleep Wake Disorders / Breast Neoplasms / Cognitive Dysfunction / Cancer Survivors Type of study: Diagnostic_studies / Etiology_studies Limits: Adult / Female / Humans / Middle aged Language: En Year: 2018 Type: Article