The intrinsic basicity of the phosphate backbone exceeds that of uracil and thymine residues: protonation of the phosphate moiety is preferred over the nucleobase for pdThd and pUrd.

Wu, R R; Hamlow, L A; He, C C; Nei, Y-W; Berden, G; Oomens, J; Rodgers, M T

Wu, R R; Hamlow, L A; He, C C; Nei, Y-W; Berden, G; Oomens, J; Rodgers, M T.

Affiliation

Wu RR; Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA. mrodgers@chem.wayne.edu.

Phys Chem Chem Phys ; 19(45): 30351-30361, 2017 Nov 22.

Article in En | MEDLINE | ID: mdl-29099122

Subject(s)

Phosphoric Monoester Hydrolases/chemistry; Thymidine Monophosphate/chemistry; Thymine/chemistry; Uracil/chemistry; Hydrogen Bonding; Molecular Conformation; Phosphates; Spectrophotometry, Infrared; Uridine/chemistry

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Full text: 1 Database: MEDLINE Main subject: Thymidine Monophosphate / Thymine / Uracil / Phosphoric Monoester Hydrolases Language: En Year: 2017 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Thymidine Monophosphate / Thymine / Uracil / Phosphoric Monoester Hydrolases Language: En Year: 2017 Type: Article