Profilin Directly Promotes Microtubule Growth through Residues Mutated in Amyotrophic Lateral Sclerosis.

Henty-Ridilla, Jessica L; Juanes, M Angeles; Goode, Bruce L

Henty-Ridilla, Jessica L; Juanes, M Angeles; Goode, Bruce L.

Affiliation

Henty-Ridilla JL; Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA.
Juanes MA; Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA.
Goode BL; Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA. Electronic address: goode@brandeis.edu.

Curr Biol ; 27(22): 3535-3543.e4, 2017 Nov 20.

Article in En | MEDLINE | ID: mdl-29129529

Subject(s)

Profilins/genetics; Profilins/metabolism; Actins/metabolism; Amyotrophic Lateral Sclerosis/genetics; Amyotrophic Lateral Sclerosis/metabolism; Animals; Cytoskeleton/metabolism; Humans; Mice; Microtubules/genetics; Microtubules/metabolism; Mutation; Profilins/physiology; Tubulin/metabolism

Key words

ALS; actin; crosstalk; microtubule; neurodegeneration; profilin; structure; tubulin

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