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Orlistat-induced oxalate nephropathy: an under-recognised cause of chronic kidney disease.
Solomon, Laurence Richard; Nixon, Andrew Christopher; Ogden, Leanne; Nair, Beena.
Affiliation
  • Solomon LR; Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.
  • Nixon AC; Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.
  • Ogden L; Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.
  • Nair B; Department of Histopathology, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.
BMJ Case Rep ; 20172017 Nov 12.
Article in En | MEDLINE | ID: mdl-29133578
ABSTRACT
Two patients developed kidney failure due to oxalate deposition in the kidney while taking orlistat. Cessation of orlistat was followed by partial recovery of kidney function. The mechanism by which orlistat causes hyperoxaluria and the management of orlistat-induced oxalate nephropathy is reviewed. We suggest that all patients taking orlistat are at risk of this condition, which may develop insidiously and is easily overlooked. Monitoring of kidney function of patients taking orlistat is warranted.
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Full text: 1 Database: MEDLINE Main subject: Hyperoxaluria / Anti-Obesity Agents / Renal Insufficiency, Chronic / Kidney Tubular Necrosis, Acute / Lactones Limits: Aged / Female / Humans / Male Language: En Year: 2017 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Hyperoxaluria / Anti-Obesity Agents / Renal Insufficiency, Chronic / Kidney Tubular Necrosis, Acute / Lactones Limits: Aged / Female / Humans / Male Language: En Year: 2017 Type: Article