Identification of alpha-gal sensitivity in patients with a diagnosis of idiopathic anaphylaxis.
Allergy
; 73(5): 1131-1134, 2018 05.
Article
in En
| MEDLINE
| ID: mdl-29161766
ABSTRACT
IgE antibodies (Ab) specific to galactose-α-1,3-galactose (alpha-gal) are responsible for a delayed form of anaphylaxis that occurs 3-6 hours after red meat ingestion. In a unique prospective study of seventy participants referred with a diagnosis of idiopathic anaphylaxis (IA), six (9%) were found to have IgE to alpha-gal. Upon institution of a diet free of red meat, all patients had no further episodes of anaphylaxis. Two of these individuals had indolent systemic mastocytosis (ISM). Those with ISM had more severe clinical reactions but lower specific IgE to alpha-gal and higher serum tryptase levels, reflective of the mast cell burden. The identification of alpha-gal syndrome in patients with IA supports the need for routine screening for this sensitivity as a cause of anaphylaxis, where reactions to alpha-gal are delayed and thus may be overlooked.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Red Meat
/
Food Hypersensitivity
/
Galactose
/
Anaphylaxis
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Animals
/
Humans
/
Male
/
Middle aged
Language:
En
Year:
2018
Type:
Article