The regulatory G4 motif of the Kirsten ras (KRAS) gene is sensitive to guanine oxidation: implications on transcription.

Cogoi, Susanna; Ferino, Annalisa; Miglietta, Giulia; Pedersen, Erik B; Xodo, Luigi E

Cogoi, Susanna; Ferino, Annalisa; Miglietta, Giulia; Pedersen, Erik B; Xodo, Luigi E.

Affiliation

Cogoi S; Department of Medicine, University of Udine, 33100 Udine, Italy.
Ferino A; Department of Medicine, University of Udine, 33100 Udine, Italy.
Miglietta G; Department of Medicine, University of Udine, 33100 Udine, Italy.
Pedersen EB; Nucleic Acid Center, Institute of Physics and Chemistry, University of Southern Denmark, DK-5230 Odense, Denmark.
Xodo LE; Department of Medicine, University of Udine, 33100 Udine, Italy.

Nucleic Acids Res ; 46(2): 661-676, 2018 01 25.

Article in En | MEDLINE | ID: mdl-29165690

Subject(s)

G-Quadruplexes; Guanine/analogs & derivatives; Proto-Oncogene Proteins p21(ras)/chemistry; Transcription Initiation Site; Transcription, Genetic; Cell Line, Tumor; DNA/chemistry; DNA/genetics; DNA/metabolism; DNA Glycosylases/genetics; DNA Glycosylases/metabolism; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Guanine/chemistry; Guanine/metabolism; HEK293 Cells; Heterogeneous Nuclear Ribonucleoprotein A1/genetics; Heterogeneous Nuclear Ribonucleoprotein A1/metabolism; Humans; Oxidation-Reduction; Promoter Regions, Genetic/genetics; Protein Binding; Proto-Oncogene Proteins p21(ras)/genetics; Proto-Oncogene Proteins p21(ras)/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism

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Full text: 1 Database: MEDLINE Main subject: Transcription, Genetic / Proto-Oncogene Proteins p21(ras) / Transcription Initiation Site / G-Quadruplexes / Guanine Type of study: Diagnostic_studies Limits: Humans Language: En Year: 2018 Type: Article

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