The properdin pathway: an "alternative activation pathway" or a "critical amplification loop" for C3 and C5 activation?

Harrison, Richard A

Harrison, Richard A.

Affiliation

Harrison RA; Institute of Infection and Immunity, School of Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, CF14 4XN, UK. richard.alexander.harrison@outlook.com.

Semin Immunopathol ; 40(1): 15-35, 2018 01.

Article in En | MEDLINE | ID: mdl-29167939

Subject(s)

Complement Pathway, Alternative; Properdin/metabolism; Signal Transduction; Animals; Carrier Proteins/metabolism; Cell Membrane/immunology; Cell Membrane/metabolism; Complement Activation/immunology; Complement C3 Nephritic Factor/immunology; Complement C3 Nephritic Factor/metabolism; Complement C3-C5 Convertases/chemistry; Complement C3-C5 Convertases/immunology; Complement C3-C5 Convertases/metabolism; Complement C3b Inactivator Proteins/immunology; Complement C3b Inactivator Proteins/metabolism; Elapid Venoms/immunology; Elapid Venoms/metabolism; Host-Pathogen Interactions/immunology; Humans; Properdin/immunology; Protein Binding

Key words

Amplification loop; C3; Properdin; Regulation; Therapy

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Full text: 1 Database: MEDLINE Main subject: Properdin / Signal Transduction / Complement Pathway, Alternative Limits: Animals / Humans Language: En Year: 2018 Type: Article

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