Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-&#954;B signaling in an IL-6-dependent manner.

Sun, Lin; Li, Man; Ma, Xun; Feng, Haoyu; Song, Junlai; Lv, Cong; He, Yajun

Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-κB signaling in an IL-6-dependent manner.

Sun, Lin; Li, Man; Ma, Xun; Feng, Haoyu; Song, Junlai; Lv, Cong; He, Yajun.

Affiliation

Sun L; Department of Orthopedics, Shanxi Academy of Medical Sciences, Shanxi Da Yi Hospital, Shanxi Da Yi Hospital affiliated to Shanxi Medical University, Taiyuan, 030032, China. sunlin_9999@163.com.
Li M; Department of Neurology, Second Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, 030001, China.
Ma X; Department of Orthopedics, Shanxi Academy of Medical Sciences, Shanxi Da Yi Hospital, Shanxi Da Yi Hospital affiliated to Shanxi Medical University, Taiyuan, 030032, China.
Feng H; Department of Orthopedics, Shanxi Academy of Medical Sciences, Shanxi Da Yi Hospital, Shanxi Da Yi Hospital affiliated to Shanxi Medical University, Taiyuan, 030032, China.
Song J; Department of Orthopedics, Shanxi Academy of Medical Sciences, Shanxi Da Yi Hospital, Shanxi Da Yi Hospital affiliated to Shanxi Medical University, Taiyuan, 030032, China.
Lv C; Department of Orthopedics, Shanxi Academy of Medical Sciences, Shanxi Da Yi Hospital, Shanxi Da Yi Hospital affiliated to Shanxi Medical University, Taiyuan, 030032, China.
He Y; Department of Orthopedics, Shanxi Academy of Medical Sciences, Shanxi Da Yi Hospital, Shanxi Da Yi Hospital affiliated to Shanxi Medical University, Taiyuan, 030032, China.

J Neuroinflammation ; 14(1): 231, 2017 Nov 25.

Article in En | MEDLINE | ID: mdl-29178911

Subject(s)

Aquaporin 4/biosynthesis; Astrocytes/pathology; HMGB1 Protein/metabolism; Spinal Cord Injuries/pathology; Animals; Astrocytes/metabolism; Interleukin-6/metabolism; NF-kappa B/metabolism; Rats; Rats, Sprague-Dawley; Reperfusion Injury/metabolism; Reperfusion Injury/pathology; Signal Transduction/physiology; Spinal Cord Injuries/metabolism; Toll-Like Receptor 4/metabolism

Key words

Aquaporin-4; Astrocyte swelling; High mobility group box-1; Interleukin-6; Nuclear factor-kappa B; Spinal cord injury; Toll-like receptor 4

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Full text: 1 Database: MEDLINE Main subject: Spinal Cord Injuries / Astrocytes / HMGB1 Protein / Aquaporin 4 Type of study: Prognostic_studies Limits: Animals Language: En Year: 2017 Type: Article

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