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Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth.
Germano, Giovanni; Lamba, Simona; Rospo, Giuseppe; Barault, Ludovic; Magrì, Alessandro; Maione, Federica; Russo, Mariangela; Crisafulli, Giovanni; Bartolini, Alice; Lerda, Giulia; Siravegna, Giulia; Mussolin, Benedetta; Frapolli, Roberta; Montone, Monica; Morano, Federica; de Braud, Filippo; Amirouchene-Angelozzi, Nabil; Marsoni, Silvia; D'Incalci, Maurizio; Orlandi, Armando; Giraudo, Enrico; Sartore-Bianchi, Andrea; Siena, Salvatore; Pietrantonio, Filippo; Di Nicolantonio, Federica; Bardelli, Alberto.
Affiliation
  • Germano G; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • Lamba S; University of Turin, Department of Oncology, Candiolo 10060, Turin, Italy.
  • Rospo G; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • Barault L; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • Magrì A; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • Maione F; University of Turin, Department of Oncology, Candiolo 10060, Turin, Italy.
  • Russo M; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • Crisafulli G; University of Turin, Department of Oncology, Candiolo 10060, Turin, Italy.
  • Bartolini A; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • Lerda G; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • Siravegna G; University of Turin, Department of Oncology, Candiolo 10060, Turin, Italy.
  • Mussolin B; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • Frapolli R; University of Turin, Department of Oncology, Candiolo 10060, Turin, Italy.
  • Montone M; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • Morano F; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • de Braud F; University of Turin, Department of Oncology, Candiolo 10060, Turin, Italy.
  • Amirouchene-Angelozzi N; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • Marsoni S; University of Turin, Department of Oncology, Candiolo 10060, Turin, Italy.
  • D'Incalci M; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • Orlandi A; IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan 20156, Italy.
  • Giraudo E; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • Sartore-Bianchi A; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy.
  • Siena S; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy.
  • Pietrantonio F; Department of Oncology and Hemat-Oncology Università degli Studi di Milano, Milan 20122, Italy.
  • Di Nicolantonio F; Candiolo Cancer Institute - FPO, IRCCS, Candiolo 10060, Turin, Italy.
  • Bardelli A; FIRC Institute of Molecular Oncology (IFOM), Milan 20139, Italy.
Nature ; 552(7683): 116-120, 2017 12 07.
Article in En | MEDLINE | ID: mdl-29186113
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Full text: 1 Database: MEDLINE Main subject: DNA Mismatch Repair / Immunotherapy / Antigens, Neoplasm / Neoplasms Limits: Animals Language: En Year: 2017 Type: Article
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Full text: 1 Database: MEDLINE Main subject: DNA Mismatch Repair / Immunotherapy / Antigens, Neoplasm / Neoplasms Limits: Animals Language: En Year: 2017 Type: Article