[Research Progress on Gene Alterations of Amelogenin Locus in Gender Identification].
Fa Yi Xue Za Zhi
; 32(5): 371-377, 2016 Oct.
Article
in Zh
| MEDLINE
| ID: mdl-29205009
ABSTRACT
There are two kinds of amelogenin gene mutation, including mutation in primer-binding region of amelogenin gene and micro deletion of Y chromosome encompassing amelogenin gene, and the latter is more common. The mechanisms of mutation in primer-binding region of amelogenin gene is nucleotide point mutation and the mechanism of micro deletion of Y chromosome encompassing amelogenin gene maybe non-allelic homologous recombination or non-homologous end-joining. Among the population worldwide, there is a notably higher frequency of amelogenin gene mutations in Indian population, Sri Lanka population and Nepalese population which reside within the Indian subcontinent. Though amelogenin gene mutations have little impact on fertility and phenotype, they might cause incorrect result in gender identification. Using composite-amplification kit which including autosomal STR locus, amelogenin gene locus and multiple Y-STR locus, could avoid wrong gender identification caused by amelogenin gene mutation.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Chromosome Aberrations
/
Chromosomes, Human, Y
/
Amelogenin
Type of study:
Diagnostic_studies
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
Zh
Year:
2016
Type:
Article