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Current Tissue Molecular Markers in Colorectal Cancer: A Literature Review.
Peluso, Gaia; Incollingo, Paola; Calogero, Armando; Tammaro, Vincenzo; Rupealta, Niccolò; Chiacchio, Gaetano; Sandoval Sotelo, Maria Laura; Minieri, Gianluca; Pisani, Antonio; Riccio, Eleonora; Sabbatini, Massimo; Bracale, Umberto Marcello; Dodaro, Concetta Anna; Carlomagno, Nicola.
Affiliation
  • Peluso G; Department of Advanced Biomedical Science, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Incollingo P; Department of Advanced Biomedical Science, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Calogero A; Department of Advanced Biomedical Science, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Tammaro V; Department of Advanced Biomedical Science, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Rupealta N; Department of Advanced Biomedical Science, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Chiacchio G; Department of Advanced Biomedical Science, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Sandoval Sotelo ML; Department of Advanced Biomedical Science, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Minieri G; Department of Advanced Biomedical Science, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Pisani A; Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Riccio E; Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Sabbatini M; Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Bracale UM; Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Dodaro CA; Department of Advanced Biomedical Science, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
  • Carlomagno N; Department of Advanced Biomedical Science, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.
Biomed Res Int ; 2017: 2605628, 2017.
Article in En | MEDLINE | ID: mdl-29214162
ABSTRACT

BACKGROUND:

Colorectal cancer (CRC) is one of the most spread neoplasia types all around the world, especially in western areas. It evolves from precancerous lesions and adenomatous polyps, through successive genetic and epigenetic mutations. Numerous risk factors intervene in its development and they are either environmental or genetic. AIM OF THE REVIEW Alongside common screening techniques, such as fecal screening tests, endoscopic evaluation, and CT-colonography, we have identified the most important and useful biomarkers and we have analyzed their role in the diagnosis, prevention, and prognosis of CRC.

CONCLUSION:

Biomarkers can become an important tool in the diagnostic and therapeutic process for CRC. But further studies are needed to identify a noninvasive, cost-effective, and highly sensible and specific screening test for their detection and to standardize their use in clinical practice.
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Full text: 1 Database: MEDLINE Main subject: Colorectal Neoplasms / Biomarkers, Tumor Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Year: 2017 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Colorectal Neoplasms / Biomarkers, Tumor Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Year: 2017 Type: Article