Recent Advances in Enzymatic Complexity Generation: Cyclization Reactions.
Biochemistry
; 57(22): 3087-3104, 2018 06 05.
Article
in En
| MEDLINE
| ID: mdl-29236467
ABSTRACT
Enzymes in biosynthetic pathways, especially in plant and microbial metabolism, generate structural and functional group complexity in small molecules by conversion of acyclic frameworks to cyclic scaffolds via short, efficient routes. The distinct chemical logic used by several distinct classes of cyclases, oxidative and non-oxidative, has recently been elucidated by genome mining, heterologous expression, and genetic and mechanistic analyses. These include enzymes performing pericyclic transformations, pyran synthases, tandem acting epoxygenases, and epoxide "hydrolases", as well as oxygenases and radical S-adenosylmethionine enzymes that involve rearrangements of substrate radicals under aerobic or anaerobic conditions.
Full text:
1
Database:
MEDLINE
Main subject:
Cyclization
/
Enzymes
/
Multienzyme Complexes
Limits:
Animals
/
Humans
Language:
En
Year:
2018
Type:
Article