Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment.

Patel, Hitisha K; Bihani, Teeru

Patel, Hitisha K; Bihani, Teeru.

Affiliation

Patel HK; Radius Health, Inc, Waltham, MA, USA.
Bihani T; Radius Health, Inc, Waltham, MA, USA. Electronic address: tbihani@radiuspharm.com.

Pharmacol Ther ; 186: 1-24, 2018 06.

Article in En | MEDLINE | ID: mdl-29289555

Subject(s)

Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Breast Neoplasms/drug therapy; Estrogen Receptor Antagonists/therapeutic use; Receptors, Estrogen/metabolism; Selective Estrogen Receptor Modulators/therapeutic use; Antineoplastic Combined Chemotherapy Protocols/administration & dosage; Antineoplastic Combined Chemotherapy Protocols/chemistry; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Chemotherapy, Adjuvant; Drug Resistance, Neoplasm/drug effects; Estrogen Receptor Antagonists/administration & dosage; Estrogen Receptor Antagonists/chemistry; Female; Humans; Molecular Structure; Selective Estrogen Receptor Modulators/administration & dosage; Selective Estrogen Receptor Modulators/chemistry

Key words

Estrogen receptor; SERD; SERM; antiestrogen; breast cancer; endocrine resistance

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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Receptors, Estrogen / Selective Estrogen Receptor Modulators / Estrogen Receptor Antagonists Limits: Female / Humans Language: En Year: 2018 Type: Article

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