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Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFß, in Advanced Solid Tumors.
Strauss, Julius; Heery, Christopher R; Schlom, Jeffrey; Madan, Ravi A; Cao, Liang; Kang, Zhigang; Lamping, Elizabeth; Marté, Jennifer L; Donahue, Renee N; Grenga, Italia; Cordes, Lisa; Christensen, Olaf; Mahnke, Lisa; Helwig, Christoph; Gulley, James L.
Affiliation
  • Strauss J; Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland.
  • Heery CR; Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland.
  • Schlom J; Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland.
  • Madan RA; Genitourinary Malignancies Branch, National Cancer Institute, NIH, Bethesda, Maryland.
  • Cao L; Molecular Targets Core, Genetics Branch, National Cancer Institute, NIH, Bethesda, Maryland.
  • Kang Z; Molecular Targets Core, Genetics Branch, National Cancer Institute, NIH, Bethesda, Maryland.
  • Lamping E; The Basic Science Program, Leidos Biomedical Research, Inc., Frederick, Maryland.
  • Marté JL; Office of Research Nursing, National Cancer Institute, NIH, Bethesda, Maryland.
  • Donahue RN; Genitourinary Malignancies Branch, National Cancer Institute, NIH, Bethesda, Maryland.
  • Grenga I; Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland.
  • Cordes L; Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH, Bethesda, Maryland.
  • Christensen O; Pharmacy Department, Clinical Center, NIH, Bethesda, Maryland.
  • Mahnke L; EMD Serono, Billerica, Massachusetts.
  • Helwig C; EMD Serono, Billerica, Massachusetts.
  • Gulley JL; Merck KGaA, Darmstadt, Germany.
Clin Cancer Res ; 24(6): 1287-1295, 2018 03 15.
Article in En | MEDLINE | ID: mdl-29298798
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Full text: 1 Database: MEDLINE Main subject: Transforming Growth Factor beta / Antibodies, Bispecific / B7-H1 Antigen / Antineoplastic Agents, Immunological / Neoplasms Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Year: 2018 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Transforming Growth Factor beta / Antibodies, Bispecific / B7-H1 Antigen / Antineoplastic Agents, Immunological / Neoplasms Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Year: 2018 Type: Article