Lentivirus-mediated shRNA Targeting CNN2 Inhibits Hepatocarcinoma <i>in Vitro</i> and <i>in Vivo</i>.

Kang, Xueqing; Wang, Feng; Lan, Xiuwan; Li, Xiaolong; Zheng, Shunxin; Lv, Zhilue; Zhuang, Yuan; Zhao, Yongxiang; Zhou, Sufang

Lentivirus-mediated shRNA Targeting CNN2 Inhibits Hepatocarcinoma in Vitro and in Vivo.

Kang, Xueqing; Wang, Feng; Lan, Xiuwan; Li, Xiaolong; Zheng, Shunxin; Lv, Zhilue; Zhuang, Yuan; Zhao, Yongxiang; Zhou, Sufang.

Affiliation

Kang X; Department of Biochemistry and Molecular Biology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, the Guangxi Zhuang Autonomous Region, China.
Wang F; Department of Biochemistry and Molecular Biology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, the Guangxi Zhuang Autonomous Region, China.
Lan X; Department of Biochemistry and Molecular Biology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, the Guangxi Zhuang Autonomous Region, China.
Li X; Department of Biochemistry and Molecular Biology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, the Guangxi Zhuang Autonomous Region, China.
Zheng S; Department of Biochemistry and Molecular Biology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, the Guangxi Zhuang Autonomous Region, China.
Lv Z; Department of Biochemistry and Molecular Biology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, the Guangxi Zhuang Autonomous Region, China.
Zhuang Y; Department of Biochemistry and Molecular Biology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, the Guangxi Zhuang Autonomous Region, China.
Zhao Y; Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy Research, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, the Guangxi Zhuang Autonomous Region, China.
Zhou S; Department of Biochemistry and Molecular Biology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, the Guangxi Zhuang Autonomous Region, China.

Int J Med Sci ; 15(1): 69-76, 2018.

Article in En | MEDLINE | ID: mdl-29333089

Subject(s)

Calcium-Binding Proteins/metabolism; Calmodulin-Binding Proteins/metabolism; Carcinoma, Hepatocellular/pathology; Liver Neoplasms/pathology; Microfilament Proteins/metabolism; Animals; Calcium-Binding Proteins/antagonists & inhibitors; Calcium-Binding Proteins/genetics; Calmodulin-Binding Proteins/antagonists & inhibitors; Calmodulin-Binding Proteins/genetics; Carcinoma, Hepatocellular/drug therapy; Carcinoma, Hepatocellular/genetics; Cell Line, Tumor; Cell Movement/genetics; Cell Proliferation/genetics; Down-Regulation; Female; Gene Knockdown Techniques; Genetic Vectors/genetics; Humans; Lentivirus/genetics; Liver Neoplasms/drug therapy; Liver Neoplasms/genetics; MAP Kinase Signaling System/genetics; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microfilament Proteins/antagonists & inhibitors; Microfilament Proteins/genetics; Molecular Targeted Therapy/methods; Phosphorylation; RNA Interference; RNA, Small Interfering/genetics; S Phase Cell Cycle Checkpoints/genetics; Transfection/methods; Xenograft Model Antitumor Assays; Calponins

Key words

CNN2; Hepatocellular Carcinoma; Molecular target therapy.; shRNA

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Full text: 1 Database: MEDLINE Main subject: Calmodulin-Binding Proteins / Calcium-Binding Proteins / Carcinoma, Hepatocellular / Liver Neoplasms / Microfilament Proteins Type of study: Prognostic_studies Language: En Year: 2018 Type: Article

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