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Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability.
Randolph, John T; Krueger, A Chris; Donner, Pamela L; Pratt, John K; Liu, Dachun; Motter, Christopher E; Rockway, Todd W; Tufano, Michael D; Wagner, Rolf; Lim, Hock B; Beyer, Jill M; Mondal, Rubina; Panchal, Neeta S; Colletti, Lynn; Liu, Yaya; Koev, Gennadiy; Kati, Warren M; Hernandez, Lisa E; Beno, David W A; Longenecker, Kenton L; Stewart, Kent D; Dumas, Emily O; Molla, Akhteruzzaman; Maring, Clarence J.
Affiliation
  • Randolph JT; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Krueger AC; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Donner PL; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Pratt JK; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Liu D; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Motter CE; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Rockway TW; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Tufano MD; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Wagner R; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Lim HB; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Beyer JM; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Mondal R; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Panchal NS; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Colletti L; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Liu Y; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Koev G; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Kati WM; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Hernandez LE; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Beno DWA; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Longenecker KL; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Stewart KD; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Dumas EO; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Molla A; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
  • Maring CJ; Research and Development, AbbVie Inc. , North Chicago, Illinois 60064, United States.
J Med Chem ; 61(3): 1153-1163, 2018 02 08.
Article in En | MEDLINE | ID: mdl-29342358
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Full text: 1 Database: MEDLINE Main subject: Stilbenes / Sulfonamides / Viral Nonstructural Proteins / Hepacivirus / Cytosine / Enzyme Inhibitors Limits: Humans Language: En Year: 2018 Type: Article
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Stilbenes / Sulfonamides / Viral Nonstructural Proteins / Hepacivirus / Cytosine / Enzyme Inhibitors Limits: Humans Language: En Year: 2018 Type: Article