Important role of endothelium-dependent hyperpolarization in the pulmonary microcirculation in male mice: implications for hypoxia-induced pulmonary hypertension.

Tanaka, Shuhei; Shiroto, Takashi; Godo, Shigeo; Saito, Hiroki; Ikumi, Yosuke; Ito, Akiyo; Kajitani, Shoko; Sato, Saori; Shimokawa, Hiroaki

Tanaka, Shuhei; Shiroto, Takashi; Godo, Shigeo; Saito, Hiroki; Ikumi, Yosuke; Ito, Akiyo; Kajitani, Shoko; Sato, Saori; Shimokawa, Hiroaki.

Affiliation

Tanaka S; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Shiroto T; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Godo S; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Saito H; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Ikumi Y; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Ito A; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Kajitani S; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Sato S; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.
Shimokawa H; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine , Sendai , Japan.

Am J Physiol Heart Circ Physiol ; 314(5): H940-H953, 2018 05 01.

Article in En | MEDLINE | ID: mdl-29351457

Subject(s)

Biological Factors/metabolism; Endothelium, Vascular/physiopathology; Hypertension, Pulmonary/etiology; Hypoxia/complications; Microcirculation; Pulmonary Artery/physiopathology; Pulmonary Circulation; Vasodilation; Animals; Disease Models, Animal; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Hypertension, Pulmonary/metabolism; Hypertension, Pulmonary/physiopathology; Hypoxia/metabolism; Hypoxia/physiopathology; Male; Membrane Potentials; Mice, Inbred C57BL; Microcirculation/drug effects; Nitric Oxide/metabolism; Pulmonary Artery/drug effects; Pulmonary Circulation/drug effects; Signal Transduction; Tyrosine/analogs & derivatives; Tyrosine/metabolism; Vascular Remodeling; Vasodilation/drug effects; Vasodilator Agents/pharmacology

Key words

endothelium-dependent hyperpolarization; hypoxia; pulmonary microcirculation

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Full text: 1 Database: MEDLINE Main subject: Pulmonary Artery / Vasodilation / Endothelium, Vascular / Biological Factors / Pulmonary Circulation / Hypertension, Pulmonary / Hypoxia / Microcirculation Type of study: Prognostic_studies Limits: Animals Language: En Year: 2018 Type: Article

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