Higher tacrolimus blood concentration is related to increased risk of post-transplantation diabetes mellitus after living donor liver transplantation.
Int J Surg
; 51: 17-23, 2018 Mar.
Article
in En
| MEDLINE
| ID: mdl-29360611
ABSTRACT
BACKGROUND/AIMS:
To investigate the association between tacrolimus (TAC) blood concentration and the risk of post-transplantation diabetes mellitus (PTDM) development after living donor liver transplantation (LDLT).METHODS:
This study reviewed the clinical data of 158 adult LDLT recipients. A cut-off of mean trough concentration of TAC (cTAC) value at the sixth month postoperatively was identified using a receptor operating characteristic curve. Other clinical complications rates were compared between different cTAC groups.RESULTS:
Thirty-four (21.5%) recipients developed PTDM during follow-up period. Recipients with PTDM suffered lower 1-, 5- and 10-year overall survival rates (85.2%, 64.9%, and 55.6% vs 92.4%, 81.4%, and 79.1%, pâ¯<â¯0.05) and allograft survival rates (87.9%, 76.9%, and 65.9% vs 94.1%, 88.5%, and 86.0%, pâ¯<â¯0.05) than those without PTDM. The best cut-off value of mean cTAC was 5.9â¯ng/mL. Recipients with higher cTAC (>5.9â¯ng/mL) were more likely to develop hyperlipidemia (39.6% vs 21.9%, pâ¯<â¯0.05), cardio-cerebral events (7.5% vs1.0%, pâ¯<â¯0.05), and infections (37.7% vs19.0%, pâ¯<â¯0.05) than recipients exposed to low cTAC (≤5.9â¯ng/mL). However, the two groups showed no difference in the incidence of acute and chronic rejection.CONCLUSION:
Higher mean cTAC at the sixth month postoperatively is related to increased risk of PTDM in LDLT recipients.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Postoperative Complications
/
Liver Transplantation
/
Tacrolimus
/
Diabetes Mellitus
/
Immunosuppressive Agents
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Year:
2018
Type:
Article