Whipple's Disease with Long-term Endoscopic Follow-up.
Intern Med
; 57(12): 1707-1713, 2018 Jun 15.
Article
in En
| MEDLINE
| ID: mdl-29434152
ABSTRACT
A 72-year-old man presented with anorexia and 15-kg weight loss over 3 years. Endoscopy revealed yellow, shaggy mucosa alternating with erythematous, eroded mucosa in the duodenum. Biopsy specimens showed massive infiltration of periodic acid-Schiff-positive macrophages in the lamina propria, consistent with Whipple's disease. The patient was treated with intravenous ceftriaxone for four weeks, followed by oral trimethoprim-sulfamethoxazole. His condition improved, and he gradually gained weight. Although the endoscopic findings improved with continuous trimethoprim-sulfamethoxazole administration, macrophage infiltration of the duodenal mucosa persisted. However, the patient has been symptom-free for eight years.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Ceftriaxone
/
Endoscopy
/
Whipple Disease
/
Anti-Bacterial Agents
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Humans
/
Male
Language:
En
Year:
2018
Type:
Article