Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J Mice Exacerbates Experimental Atherosclerosis.

Vozenilek, Aimee E; Vetkoetter, Matthew; Green, Jonette M; Shen, Xinggui; Traylor, James G; Klein, Ronald L; Orr, A Wayne; Woolard, Matthew D; Krzywanski, David M

Vozenilek, Aimee E; Vetkoetter, Matthew; Green, Jonette M; Shen, Xinggui; Traylor, James G; Klein, Ronald L; Orr, A Wayne; Woolard, Matthew D; Krzywanski, David M.

Affiliation

Vozenilek AE; Department of Microbiology and Immunology, School of Medicine, Shreveport, Louisiana, USA.
Vetkoetter M; Center for Cardiovascular Disease and Sciences, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, USA.
Green JM; Department of Cellular Biology and Anatomy, School of Medicine, Shreveport, Louisiana, USA.
Shen X; Center for Cardiovascular Disease and Sciences, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, USA.
Traylor JG; Department of Pathology and Translational Pathobiology, School of Medicine, Shreveport, Louisiana, USA.
Klein RL; Center for Cardiovascular Disease and Sciences, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, USA.
Orr AW; Department of Pathology and Translational Pathobiology, School of Medicine, Shreveport, Louisiana, USA.
Woolard MD; Center for Cardiovascular Disease and Sciences, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, USA.
Krzywanski DM; Department of Pathology and Translational Pathobiology, School of Medicine, Shreveport, Louisiana, USA.

J Vasc Res ; 55(2): 98-110, 2018.

Article in En | MEDLINE | ID: mdl-29455203

Subject(s)

Aorta/enzymology; Aortic Diseases/enzymology; Atherosclerosis/enzymology; NADP Transhydrogenase, AB-Specific/deficiency; Animals; Antioxidants/pharmacology; Aorta/drug effects; Aorta/pathology; Aortic Diseases/genetics; Aortic Diseases/pathology; Atherosclerosis/genetics; Atherosclerosis/pathology; Cholesterol/blood; Disease Models, Animal; Genetic Predisposition to Disease; Hypercholesterolemia/enzymology; Hypercholesterolemia/genetics; Male; Mice, Inbred C57BL; Mice, Knockout; Mitochondria/drug effects; Mitochondria/metabolism; Mitochondrial Proteins/deficiency; Mitochondrial Proteins/genetics; NADP Transhydrogenase, AB-Specific/genetics; Organophosphorus Compounds/pharmacology; Phenotype; Piperidines/pharmacology; Plaque, Atherosclerotic; Proprotein Convertase 9/genetics; Proprotein Convertase 9/metabolism; Superoxides/metabolism; Time Factors

Key words

Atherosclerosis; Mitochondria; Nicotinamide nucleotide transhydrogenase; Proprotein convertase subtilisin/kexin type 9 virus; Reactive oxygen species

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Full text: 1 Database: MEDLINE Main subject: Aorta / Aortic Diseases / Atherosclerosis / NADP Transhydrogenase, AB-Specific Type of study: Prognostic_studies Limits: Animals Language: En Year: 2018 Type: Article

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