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Immune checkpoint blockade combined with IL-6 and TGF-ß inhibition improves the therapeutic outcome of mRNA-based immunotherapy.
Bialkowski, Lukasz; Van der Jeught, Kevin; Bevers, Sanne; Tjok Joe, Patrick; Renmans, Dries; Heirman, Carlo; Aerts, Joeri L; Thielemans, Kris.
Affiliation
  • Bialkowski L; Laboratory of Molecular and Cellular Therapy, Vrije Universiteit Brussel, Laarbeeklaan 103E, Brussels, 1090, Belgium.
  • Van der Jeught K; Laboratory of Molecular and Cellular Therapy, Vrije Universiteit Brussel, Laarbeeklaan 103E, Brussels, 1090, Belgium.
  • Bevers S; eTheRNA Immunotherapies, Galileilaan 19, Niel, 2845, Belgium.
  • Tjok Joe P; Laboratory of Molecular and Cellular Therapy, Vrije Universiteit Brussel, Laarbeeklaan 103E, Brussels, 1090, Belgium.
  • Renmans D; Laboratory of Molecular and Cellular Therapy, Vrije Universiteit Brussel, Laarbeeklaan 103E, Brussels, 1090, Belgium.
  • Heirman C; eTheRNA Immunotherapies, Galileilaan 19, Niel, 2845, Belgium.
  • Aerts JL; Laboratory of Molecular and Cellular Therapy, Vrije Universiteit Brussel, Laarbeeklaan 103E, Brussels, 1090, Belgium.
  • Thielemans K; Laboratory of Molecular and Cellular Therapy, Vrije Universiteit Brussel, Laarbeeklaan 103E, Brussels, 1090, Belgium.
Int J Cancer ; 143(3): 686-698, 2018 08 01.
Article in En | MEDLINE | ID: mdl-29464699
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Full text: 1 Database: MEDLINE Main subject: RNA, Messenger / Transforming Growth Factor beta / Interleukin-6 / Antineoplastic Agents, Immunological / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2018 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: RNA, Messenger / Transforming Growth Factor beta / Interleukin-6 / Antineoplastic Agents, Immunological / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Year: 2018 Type: Article