Thiol-Reactive Bifunctional Chelators for the Creation of Site-Selectively Modified Radioimmunoconjugates with Improved Stability.

Adumeau, Pierre; Davydova, Maria; Zeglis, Brian M

Adumeau, Pierre; Davydova, Maria; Zeglis, Brian M.

Affiliation

Adumeau P; Department of Chemistry , Hunter College of the City University of New York , New York , New York 10028 , United States.
Davydova M; Department of Radiology , Memorial Sloan Kettering Cancer Center , New York , New York 10065 , United States.
Zeglis BM; Department of Chemistry , Hunter College of the City University of New York , New York , New York 10028 , United States.

Bioconjug Chem ; 29(4): 1364-1372, 2018 04 18.

Article in En | MEDLINE | ID: mdl-29509393

Subject(s)

Chelating Agents/chemistry; Immunoconjugates/chemistry; Lutetium/chemistry; Mesylates/chemistry; Radioisotopes/chemistry; Sulfhydryl Compounds/chemistry; Zirconium/chemistry; Animals; Chelating Agents/pharmacokinetics; Humans; Immunoconjugates/pharmacokinetics; Lutetium/pharmacokinetics; Mesylates/pharmacokinetics; Mice; Mice, Nude; Neoplasms/diagnostic imaging; Positron-Emission Tomography/methods; Radioisotopes/pharmacokinetics; Zirconium/pharmacokinetics

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Full text: 1 Database: MEDLINE Main subject: Radioisotopes / Sulfhydryl Compounds / Zirconium / Chelating Agents / Mesylates / Immunoconjugates / Lutetium Limits: Animals / Humans Language: En Year: 2018 Type: Article

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