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Creation of knock out and knock in mice by CRISPR/Cas9 to validate candidate genes for human male infertility, interest, difficulties and feasibility.
Kherraf, Zine-Eddine; Conne, Beatrice; Amiri-Yekta, Amir; Kent, Marie Christou; Coutton, Charles; Escoffier, Jessica; Nef, Serge; Arnoult, Christophe; Ray, Pierre F.
Affiliation
  • Kherraf ZE; Genetic Epigenetic and Therapies of Infertility, Institute for Advanced Biosciences, Inserm U1209, CNRS UMR 5309, Université Grenoble Alpes, F-38000, Grenoble, France; UM GI-DPI, CHU Grenoble Alpes, Grenoble, F-38000, France.
  • Conne B; Department of Genetic Medicine and Development University of Geneva Medical School, CH 1211, Geneva 4, Switzerland.
  • Amiri-Yekta A; Genetic Epigenetic and Therapies of Infertility, Institute for Advanced Biosciences, Inserm U1209, CNRS UMR 5309, Université Grenoble Alpes, F-38000, Grenoble, France; UM GI-DPI, CHU Grenoble Alpes, Grenoble, F-38000, France; Reproductive Biomedicine Research Center, Royan Institute for Reproductive
  • Kent MC; Genetic Epigenetic and Therapies of Infertility, Institute for Advanced Biosciences, Inserm U1209, CNRS UMR 5309, Université Grenoble Alpes, F-38000, Grenoble, France.
  • Coutton C; Genetic Epigenetic and Therapies of Infertility, Institute for Advanced Biosciences, Inserm U1209, CNRS UMR 5309, Université Grenoble Alpes, F-38000, Grenoble, France; UM de Génétique Chromosomique, CHU de Grenoble, Grenoble, F-38000, France.
  • Escoffier J; Genetic Epigenetic and Therapies of Infertility, Institute for Advanced Biosciences, Inserm U1209, CNRS UMR 5309, Université Grenoble Alpes, F-38000, Grenoble, France.
  • Nef S; Department of Genetic Medicine and Development University of Geneva Medical School, CH 1211, Geneva 4, Switzerland.
  • Arnoult C; Genetic Epigenetic and Therapies of Infertility, Institute for Advanced Biosciences, Inserm U1209, CNRS UMR 5309, Université Grenoble Alpes, F-38000, Grenoble, France.
  • Ray PF; Genetic Epigenetic and Therapies of Infertility, Institute for Advanced Biosciences, Inserm U1209, CNRS UMR 5309, Université Grenoble Alpes, F-38000, Grenoble, France; UM GI-DPI, CHU Grenoble Alpes, Grenoble, F-38000, France. Electronic address: pray@chu-grenoble.fr.
Mol Cell Endocrinol ; 468: 70-80, 2018 06 15.
Article in En | MEDLINE | ID: mdl-29522859
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Full text: 1 Database: MEDLINE Main subject: Gene Knock-In Techniques / Genetic Association Studies / CRISPR-Cas Systems / CRISPR-Associated Protein 9 / Infertility, Male Limits: Animals / Female / Humans / Male Language: En Year: 2018 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Gene Knock-In Techniques / Genetic Association Studies / CRISPR-Cas Systems / CRISPR-Associated Protein 9 / Infertility, Male Limits: Animals / Female / Humans / Male Language: En Year: 2018 Type: Article