Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

Hammill, Jared T; Scott, Daniel C; Min, Jaeki; Connelly, Michele C; Holbrook, Gloria; Zhu, Fangyi; Matheny, Amy; Yang, Lei; Singh, Bhuvanesh; Schulman, Brenda A; Guy, R Kiplin

Hammill, Jared T; Scott, Daniel C; Min, Jaeki; Connelly, Michele C; Holbrook, Gloria; Zhu, Fangyi; Matheny, Amy; Yang, Lei; Singh, Bhuvanesh; Schulman, Brenda A; Guy, R Kiplin.

Affiliation

Hammill JT; Department of Chemical Biology and Theraputics , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 United States.
Scott DC; Howard Hughes Medical Institute , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 United States.
Min J; Department of Structural Biology , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 United States.
Connelly MC; Department of Chemical Biology and Theraputics , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 United States.
Holbrook G; Department of Chemical Biology and Theraputics , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 United States.
Zhu F; Department of Chemical Biology and Theraputics , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 United States.
Matheny A; Department of Chemical Biology and Theraputics , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 United States.
Yang L; Department of Chemical Biology and Theraputics , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 United States.
Singh B; Department of Chemical Biology and Theraputics , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 United States.
Schulman BA; Department of Surgery, Laboratory of Epithelial Cancer Biology , Memorial Sloan Kettering Cancer Center , New York , New York 10065 United States.
Guy RK; Howard Hughes Medical Institute , St. Jude Children's Research Hospital , Memphis , Tennessee 38105 United States.

J Med Chem ; 61(7): 2680-2693, 2018 04 12.

Article in En | MEDLINE | ID: mdl-29547696

Subject(s)

Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Cullin Proteins/antagonists & inhibitors; NEDD8 Protein/antagonists & inhibitors; Proto-Oncogene Proteins/antagonists & inhibitors; Carcinoma, Squamous Cell/drug therapy; Cell Line, Tumor; Crystallography, X-Ray; Drug Discovery; Drug Screening Assays, Antitumor; High-Throughput Screening Assays; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms/drug therapy; Models, Molecular; Molecular Conformation; NEDD8 Protein/metabolism; Protein Binding; Proteins; Proto-Oncogene Proteins/metabolism; Signal Transduction/drug effects; Structure-Activity Relationship; Ubiquitin-Conjugating Enzymes/antagonists & inhibitors

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Full text: 1 Database: MEDLINE Main subject: Proto-Oncogene Proteins / Cullin Proteins / NEDD8 Protein / Antineoplastic Agents Limits: Humans Language: En Year: 2018 Type: Article

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