Ranking Enzyme Structures in the PDB by Bound Ligand Similarity to Biological Substrates.

Tyzack, Jonathan D; Fernando, Laurent; Ribeiro, Antonio J M; Borkakoti, Neera; Thornton, Janet M

Tyzack, Jonathan D; Fernando, Laurent; Ribeiro, Antonio J M; Borkakoti, Neera; Thornton, Janet M.

Affiliation

Tyzack JD; EMBL-EBI, Wellcome Genome Campus, Hinxton CB10 1SD, UK. Electronic address: tyzack@ebi.ac.uk.
Fernando L; EMBL-EBI, Wellcome Genome Campus, Hinxton CB10 1SD, UK.
Ribeiro AJM; EMBL-EBI, Wellcome Genome Campus, Hinxton CB10 1SD, UK.
Borkakoti N; EMBL-EBI, Wellcome Genome Campus, Hinxton CB10 1SD, UK.
Thornton JM; EMBL-EBI, Wellcome Genome Campus, Hinxton CB10 1SD, UK.

Structure ; 26(4): 565-571.e3, 2018 04 03.

Article in En | MEDLINE | ID: mdl-29551288

Subject(s)

Acetylcholine/chemistry; Acetylcholinesterase/chemistry; Biosimilar Pharmaceuticals/chemistry; Uroporphyrinogen III Synthetase/chemistry; Uroporphyrinogens/chemistry; Acetylcholine/metabolism; Acetylcholinesterase/metabolism; Binding Sites; Biosimilar Pharmaceuticals/metabolism; Humans; Ligands; Molecular Docking Simulation; Protein Binding; Substrate Specificity; Uroporphyrinogen III Synthetase/metabolism; Uroporphyrinogens/metabolism

Key words

PDB; biological; bound; cognate; enzyme; ligand; native; relevance; similarity

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Full text: 1 Database: MEDLINE Main subject: Acetylcholinesterase / Uroporphyrinogen III Synthetase / Uroporphyrinogens / Acetylcholine / Biosimilar Pharmaceuticals Type of study: Prognostic_studies Limits: Humans Language: En Year: 2018 Type: Article

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