Dissimilar flexibility of &#945; and ß subunits of human adult hemoglobin influences the protein dynamics and its alteration induced by allosteric effectors.

Schay, Gusztáv; Kaposi, András D; Smeller, László; Szigeti, Krisztián; Fidy, Judit; Herenyi, Levente

Dissimilar flexibility of α and ß subunits of human adult hemoglobin influences the protein dynamics and its alteration induced by allosteric effectors.

Schay, Gusztáv; Kaposi, András D; Smeller, László; Szigeti, Krisztián; Fidy, Judit; Herenyi, Levente.

Affiliation

Schay G; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Kaposi AD; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Smeller L; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Szigeti K; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Fidy J; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.
Herenyi L; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary.

PLoS One ; 13(3): e0194994, 2018.

Article in En | MEDLINE | ID: mdl-29584765

Subject(s)

Hemoglobins/metabolism; Allosteric Regulation; Amino Acid Sequence; Binding Sites; Fluorescent Dyes/chemistry; Hemoglobins/chemistry; Humans; Molecular Dynamics Simulation; Oxygen/chemistry; Oxygen/metabolism; Protein Binding; Protein Structure, Quaternary; Protein Subunits/chemistry; Protein Subunits/metabolism; Sequence Alignment; Spectrometry, Fluorescence

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