Ginsenoside-Rg1 Protects against Renal Fibrosis by Regulating the Klotho/TGF-ß1/Smad Signaling Pathway in Rats with Obstructive Nephropathy.

Li, Sha-Sha; He, Ao-Lin; Deng, Zhi-Yong; Liu, Qi-Feng

Li, Sha-Sha; He, Ao-Lin; Deng, Zhi-Yong; Liu, Qi-Feng.

Affiliation

Li SS; Clinical Research & Lab Centre, Kunshan First People's Hospital Affiliated to Jiangsu University.
He AL; Clinical Research & Lab Centre, Kunshan First People's Hospital Affiliated to Jiangsu University.
Deng ZY; Department of Pathology, Kunshan First People's Hospital Affiliated to Jiangsu University.
Liu QF; Department of Nephrology, Kunshan First People's Hospital Affiliated to Jiangsu University.

Biol Pharm Bull ; 41(4): 585-591, 2018.

Article in En | MEDLINE | ID: mdl-29607931

Subject(s)

Ginsenosides/pharmacology; Kidney Diseases/metabolism; Protective Agents/pharmacology; Animals; Fibrosis; Ginsenosides/therapeutic use; Glucuronidase/metabolism; Kidney/drug effects; Kidney/metabolism; Kidney/pathology; Kidney Diseases/drug therapy; Klotho Proteins; Male; Protective Agents/therapeutic use; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins/metabolism; Transforming Growth Factor beta1/metabolism; Ureteral Obstruction/complications

Key words

Ginsenoside-Rg1; Klotho; epithelialmesenchymal transition; obstructive nephropathy; transforming growth factor-ß1

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Full text: 1 Database: MEDLINE Main subject: Protective Agents / Ginsenosides / Kidney Diseases Type of study: Prognostic_studies Limits: Animals Language: En Year: 2018 Type: Article

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