Evolution of New miRNAs and Cerebro-Cortical Development.
Annu Rev Neurosci
; 41: 119-137, 2018 07 08.
Article
in En
| MEDLINE
| ID: mdl-29618285
ABSTRACT
The noncoding portion of the genome, including microRNAs, has been fertile evolutionary soil for cortical development in primates. A major contribution to cortical expansion in primates is the generation of novel precursor cell populations. Because miRNA expression profiles track closely with cell identity, it is likely that numerous novel microRNAs have contributed to cellular diversity in the brain. The tools to determine the genomic context within which novel microRNAs emerge and how they become integrated into molecular circuitry are now in hand.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Cerebellum
/
Cerebral Cortex
/
MicroRNAs
/
Biological Evolution
/
Neural Pathways
Limits:
Animals
/
Humans
Language:
En
Year:
2018
Type:
Article