Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches.
Skin Pharmacol Physiol
; 31(3): 163-171, 2018.
Article
in En
| MEDLINE
| ID: mdl-29621751
ABSTRACT
BACKGROUND:
Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery.METHODS:
To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies.RESULTS:
Despite the lipophilic nature of HO, the HO-DMN patches had a sharp shape and uniform array, with an average length and tip diameter of 388.36 ± 16.73 and 38.54 ± 5.29 µm, respectively. The mechanical strength of the HO-DMN patches was sufficient (fracture force of 0.29 ± 0.01 N), and they could successfully penetrate pig skin. During the 4-week clinical evaluation, HO-DMN patches caused significant improvements in skin and dermal density, skin elasticity, and moisturization. Additionally, a brief safety assessment showed that the HO-DMN patches induced negligible adverse events.CONCLUSION:
The HO-DMNs are efficient, safe, and convenient for wide use in cosmetic applications for skin barrier restoration and moisturization.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Skin
/
Skin Absorption
/
Oils
/
Lubricants
Limits:
Adult
/
Animals
/
Female
/
Humans
/
Middle aged
Language:
En
Year:
2018
Type:
Article