Tryptophanyl-tRNA synthetase mediates high-affinity tryptophan uptake into human cells.

Miyanokoshi, Miki; Yokosawa, Takumi; Wakasugi, Keisuke

Miyanokoshi, Miki; Yokosawa, Takumi; Wakasugi, Keisuke.

Affiliation

Miyanokoshi M; From the Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan and.
Yokosawa T; Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Wakasugi K; From the Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan and wakasugi@bio.c.u-tokyo.ac.jp.

J Biol Chem ; 293(22): 8428-8438, 2018 06 01.

Article in En | MEDLINE | ID: mdl-29666190

Subject(s)

Leukemia, Monocytic, Acute/metabolism; Tryptophan-tRNA Ligase/metabolism; Tryptophan/metabolism; Binding Sites; Crystallography, X-Ray; HeLa Cells; Humans; Interferon-gamma/metabolism; Leukemia, Monocytic, Acute/pathology; Protein Binding; Protein Conformation; Tryptophan-tRNA Ligase/chemistry; Tumor Cells, Cultured

Key words

amino acid transport; aminoacyl tRNA synthetase; indoleamine-pyrrole 2,3-dioxygenase (IDO1); interferon; mutagenesis; tryptophan; tryptophanyl-tRNA synthetase

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Full text: 1 Database: MEDLINE Main subject: Tryptophan / Tryptophan-tRNA Ligase / Leukemia, Monocytic, Acute Limits: Humans Language: En Year: 2018 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Tryptophan / Tryptophan-tRNA Ligase / Leukemia, Monocytic, Acute Limits: Humans Language: En Year: 2018 Type: Article