Effects of different natural extracts in an experimental model of benign prostatic hyperplasia (BPH).
Inflamm Res
; 67(7): 617-626, 2018 Jul.
Article
in En
| MEDLINE
| ID: mdl-29679313
ABSTRACT
OBJECTIVE AND DESIGN:
To characterize the impact of inflammatory process and oxidative stress in the degree of benign prostatic hyperplasia (BPH), a common condition in which chronic inflammation plays a crucial role, we investigated the effect of different plant extract preparations in an in vivo model of BPH as new therapeutic target.MATERIAL:
BPH was made in rats with daily administration of testosterone propionate (3 mg/kg) for 14 days. TREATMENT Rats were randomized into different groups to receive oral administration of plant extract preparations Serenoa repens with selenium (SeR 28.5 mg/kg associated with Se 0.005 mg/kg), Teoside (2 mg/kg), and Puryprost (14 mg/kg containing Teoside 50% 2 mg/kg and Epilobium 12 mg/kg).METHODS:
After 14 days, rats were killed and histological changes, prostate weight and apoptotic pathways were assayed.RESULTS:
The results obtained demonstrated that the association of treatments reduced prostate weight and hyperplasia, while treatment with Puryprost demonstrated a greater trend of protection compared to the other treatments.CONCLUSION:
Thus, our results indicate that plant extract could be considered as new useful therapy in the treatment of BPH with particular attention on Puryprost that represents a rational approach to reduce BPH through modulation of inflammatory process and anti-oxidant process.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Prostatic Hyperplasia
/
Selenium
/
Plant Extracts
/
Serenoa
/
Ajuga
/
Epilobium
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Year:
2018
Type:
Article