Reduced expression of growth differentiation factor 11 promoted the progression of chronic obstructive pulmonary disease by activating the AKT signaling pathway.

Tang, Feng; Ling, Chunhua; Liu, Jinming

Tang, Feng; Ling, Chunhua; Liu, Jinming.

Affiliation

Tang F; Department of respiration, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; Department of Pulmonary Circulation, Department of Pulmonary Function Test, Shanghai Pulmonary Hospital, Shanghai 200433, China.
Ling C; Department of Pulmonary Circulation, Department of Pulmonary Function Test, Shanghai Pulmonary Hospital, Shanghai 200433, China. Electronic address: lingchunhua1356@163.com.
Liu J; Department of respiration, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Electronic address: liujinming2736@163.com.

Biomed Pharmacother ; 103: 691-698, 2018 Jul.

Article in En | MEDLINE | ID: mdl-29680737

Subject(s)

Bone Morphogenetic Proteins/biosynthesis; Disease Progression; Growth Differentiation Factors/biosynthesis; Proto-Oncogene Proteins c-akt/metabolism; Pulmonary Disease, Chronic Obstructive/metabolism; Signal Transduction/physiology; Aged; Animals; Biomarkers/metabolism; Bone Morphogenetic Proteins/genetics; Female; Gene Expression; Growth Differentiation Factors/genetics; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Pulmonary Disease, Chronic Obstructive/pathology; Smoking/metabolism; Smoking/pathology

Key words

AKT; Chronic obstructive pulmonary disease; Growth differentiation factor 11; Smoke

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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Disease Progression / Bone Morphogenetic Proteins / Pulmonary Disease, Chronic Obstructive / Proto-Oncogene Proteins c-akt / Growth Differentiation Factors Type of study: Risk_factors_studies Limits: Aged / Animals / Female / Humans / Male / Middle aged Language: En Year: 2018 Type: Article

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