Three-dimensional in vitro models answer the right questions in ADPKD cystogenesis.

Dixon, Eryn E; Woodward, Owen M

Dixon, Eryn E; Woodward, Owen M.

Affiliation

Dixon EE; Department of Physiology, University of Maryland School of Medicine , Baltimore, Maryland.
Woodward OM; Department of Physiology, University of Maryland School of Medicine , Baltimore, Maryland.

Am J Physiol Renal Physiol ; 315(2): F332-F335, 2018 08 01.

Article in En | MEDLINE | ID: mdl-29693448

Subject(s)

Cell Culture Techniques; Kidney/pathology; Polycystic Kidney, Autosomal Dominant/pathology; Animals; Cell Proliferation; Cells, Cultured; Cellular Microenvironment; Disease Progression; Fibrosis; Genetic Predisposition to Disease; Humans; Kidney/metabolism; Kidney/physiopathology; Mutation; Organoids/metabolism; Organoids/pathology; Phenotype; Polycystic Kidney, Autosomal Dominant/genetics; Polycystic Kidney, Autosomal Dominant/metabolism; Polycystic Kidney, Autosomal Dominant/physiopathology; Stem Cells/metabolism; Stem Cells/pathology; TRPP Cation Channels/genetics; Tissue Scaffolds

Key words

3D in vitro culture; ADPKD; organoid; polycystin; stem cell

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Full text: 1 Database: MEDLINE Main subject: Polycystic Kidney, Autosomal Dominant / Cell Culture Techniques / Kidney Limits: Animals / Humans Language: En Year: 2018 Type: Article

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