Solid pseudopapillary and malignant pancreatic tumors in childhood: A systematic review and evidence quality assessment.
Pediatr Blood Cancer
; 65(10): e27114, 2018 Oct.
Article
in En
| MEDLINE
| ID: mdl-29697193
ABSTRACT
A systematic review of 32 studies reporting on 489 children with pancreatic tumors was performed. The most prevalent histologic subtype was solid pseudopapillary tumor (SPT) (61.3%). Pancreaticoduodenectomy was the most commonly performed operation (48%). Neoadjuvant chemo/radiotherapy was utilized in 3.9, 36.2, 25, and 27.8% of patients with SPTs, pancreatoblastomas (PBLs), neuroendocrine tumors, and exocrine carcinomas, respectively. Adjuvant chemotherapy (75.6%) and radiation (34%) were most commonly utilized in PBLs. All-cause mortality was highest in exocrine carcinomas (50%). Overall, 98.8% of patients with SPTs survived. PBL exhibited the highest recurrence rate (14.7%) within a mean of 23.5 months.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Pancreatic Neoplasms
Type of study:
Systematic_reviews
Limits:
Adolescent
/
Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
Language:
En
Year:
2018
Type:
Article