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Hypoxia and tumor angiogenesis in the era of hepatocellular carcinoma transarterial loco-regional treatments.
Petrillo, Mario; Patella, Francesca; Pesapane, Filippo; Suter, Matteo B; Ierardi, Anna M; Angileri, Salvatore A; Floridi, Chiara; de Filippo, Massimo; Carrafiello, Gianpaolo.
Affiliation
  • Petrillo M; Diagnostic & Interventional Radiology Service, San Paolo Hospital, Milan, Italy.
  • Patella F; Postgraduation School of Radiodiagnostic of Milan, Department of Health Sciences, Milan, Italy.
  • Pesapane F; Postgraduation School of Radiodiagnostic of Milan, Department of Health Sciences, Milan, Italy.
  • Suter MB; Department of Medical Oncology, ASST Sette laghi, Varese, Italy.
  • Ierardi AM; Diagnostic & Interventional Radiology Service, San Paolo Hospital, Milan, Italy.
  • Angileri SA; Diagnostic & Interventional Radiology Service, San Paolo Hospital, Milan, Italy.
  • Floridi C; Department of Diagnostic & Interventional Radiology Fatebenefratelli Hospital, Milan, Italy.
  • de Filippo M; Department of Medicine & Surgery Via Gramsci Azienda Ospedaliero Universitaria di Parma, 14 Parma, Italy.
  • Carrafiello G; Diagnostic & Interventional Radiology Service, San Paolo Hospital, Milan, Italy.
Future Oncol ; 14(28): 2957-2967, 2018 Dec.
Article in En | MEDLINE | ID: mdl-29712486
ABSTRACT
This review focuses upon interactions and potential therapeutic targets in the 'vicious cycle' between hypoxia and neoangiogenesis following treatment of hepatocellular carcinoma with transarterial loco-regional therapies. Biomarkers correlated with angiogenesis have been studied by many authors as prognostic determinants following transarterial intrahepatic therapy. According to these results future therapies directed toward specific factors related to angiogenesis could play a significant role in preventing local tumor recurrence and remote metastasis.
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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Liver Neoplasms / Hypoxia / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Humans Language: En Year: 2018 Type: Article

Full text: 1 Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Liver Neoplasms / Hypoxia / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Humans Language: En Year: 2018 Type: Article