Modeling the complex etiology of holoprosencephaly in mice.

Hong, Mingi; Krauss, Robert S

Hong, Mingi; Krauss, Robert S.

Affiliation

Hong M; Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York.
Krauss RS; Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York.

Am J Med Genet C Semin Med Genet ; 178(2): 140-150, 2018 06.

Article in En | MEDLINE | ID: mdl-29749693

Subject(s)

Holoprosencephaly/etiology; Models, Biological; Multifactorial Inheritance; Animals; Biomarkers; Disease Models, Animal; Epistasis, Genetic; Gene-Environment Interaction; Genetic Association Studies; Genetic Predisposition to Disease; Hedgehog Proteins/genetics; Hedgehog Proteins/metabolism; Holoprosencephaly/diagnosis; Holoprosencephaly/metabolism; Humans; Mice; Mice, Knockout; Mutation; Nodal Protein/genetics; Nodal Protein/metabolism; Phenotype; Signal Transduction

Key words

gene-environment interaction; hedgehog signaling; holoprosencephaly; modifier genes; mouse; mutation; nodal signaling; teratogen

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Full text: 1 Database: MEDLINE Main subject: Holoprosencephaly / Multifactorial Inheritance / Models, Biological Type of study: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Year: 2018 Type: Article

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