Separation of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins.

Mastren, Tara; Stein, Benjamin W; Parker, T Gannon; Radchenko, Valery; Copping, Roy; Owens, Allison; Wyant, Lance E; Brugh, Mark; Kozimor, Stosh A; Nortier, F Meiring; Birnbaum, Eva R; John, Kevin D; Fassbender, Michael E

Mastren, Tara; Stein, Benjamin W; Parker, T Gannon; Radchenko, Valery; Copping, Roy; Owens, Allison; Wyant, Lance E; Brugh, Mark; Kozimor, Stosh A; Nortier, F Meiring; Birnbaum, Eva R; John, Kevin D; Fassbender, Michael E.

Affiliation

Mastren T; Chemistry Division , Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.
Stein BW; Chemistry Division , Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.
Parker TG; Chemistry Division , Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.
Radchenko V; Chemistry Division , Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.
Copping R; Nuclear Security and Isotope Technology Division , Oak Ridge National Laboratory , Oak Ridge , Tennessee 37831 , United States.
Owens A; Nuclear Security and Isotope Technology Division , Oak Ridge National Laboratory , Oak Ridge , Tennessee 37831 , United States.
Wyant LE; Nuclear Security and Isotope Technology Division , Oak Ridge National Laboratory , Oak Ridge , Tennessee 37831 , United States.
Brugh M; Chemistry Division , Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.
Kozimor SA; Chemistry Division , Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.
Nortier FM; Chemistry Division , Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.
Birnbaum ER; Chemistry Division , Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.
John KD; Chemistry Division , Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.
Fassbender ME; Chemistry Division , Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.

Anal Chem ; 90(11): 7012-7017, 2018 06 05.

Article in En | MEDLINE | ID: mdl-29757620

ABSTRACT

ABSTRACT

Protactinium-230 ( t1/2 = 17.4 d) is the parent isotope of 230U ( t1/2 = 20.8 d), a radionuclide of interest for targeted alpha therapy (TAT). Column chromatographic methods have been developed to separate no-carrier-added 230Pa from proton irradiated thorium targets and accompanying fission products. Results reported within demonstrate the use of novel sulfur bearing chromatographic extraction resins for the selective separation of protactinium. The recovery yield of 230Pa was 93 ± 4% employing a R3PâS type commercially available resin and 88 ± 4% employing a DGTA (diglycothioamide) containing custom synthesized extraction chromatographic resin. The radiochemical purity of the recovered 230Pa was measured via high purity germanium Î³-ray spectroscopy to be >99.5% with the remaining radioactive contaminant being 95Nb due to its similar chemistry to protactinium. Measured equilibrium distribution coefficients for protactinium, thorium, uranium, niobium, radium, and actinium on both the R3PâS type and the DGTA resin in hydrochloric acid media are reported, to the best of our knowledge, for the first time.

Subject(s)

Protactinium/isolation & purification; Resins, Synthetic/chemistry; Molecular Structure; Protactinium/chemistry; Resins, Synthetic/chemical synthesis; Surface Properties; Thymidine/analogs & derivatives; Thymidine/chemical synthesis; Thymidine/chemistry; Uranium/chemistry; Uranium/isolation & purification

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