Development and validation of a fast and sensitive UHPLC-ESI-MS method for the simultaneous quantification of spironolactone and its metabolites in ocular tissues.

Dahmana, Naoual; Gabriel, Doris; Gurny, Robert; Kalia, Yogeshvar N

Dahmana, Naoual; Gabriel, Doris; Gurny, Robert; Kalia, Yogeshvar N.

Affiliation

Dahmana N; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Lausanne, Switzerland.
Gabriel D; Apidel SA, Geneva, Switzerland.
Gurny R; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Lausanne, Switzerland.
Kalia YN; Apidel SA, Geneva, Switzerland.

Biomed Chromatogr ; 32(10): e4287, 2018 Oct.

Article in En | MEDLINE | ID: mdl-29767448

Subject(s)

Chromatography, High Pressure Liquid/methods; Cornea/chemistry; Spectrometry, Mass, Electrospray Ionization/methods; Spironolactone/analysis; Spironolactone/metabolism; Animals; Cornea/metabolism; Drug Stability; Limit of Detection; Linear Models; Reproducibility of Results; Spironolactone/chemistry; Swine; Tandem Mass Spectrometry/methods

Key words

7α-thiomethylspironolactone; canrenone; potassium canrenoate; spironolactone; ultra-high performance liquid chromatography tandem mass spectrometry

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Full text: 1 Database: MEDLINE Main subject: Spironolactone / Chromatography, High Pressure Liquid / Cornea / Spectrometry, Mass, Electrospray Ionization Type of study: Diagnostic_studies / Guideline / Prognostic_studies Limits: Animals Language: En Year: 2018 Type: Article

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