Better Together: A Hybrid Amyloid Signals Necroptosis.
Cell
; 173(5): 1068-1070, 2018 05 17.
Article
in En
| MEDLINE
| ID: mdl-29775589
ABSTRACT
A new solid-state NMR study determines the high-resolution hetero-amyloid structure of the RIPK1-RIPK3 signaling complex that is involved in mediating necroptosis. The structure demonstrates specific formation of hetero-amyloids over homo-amyloids and the structural basis for a functional amyloid to act as a platform to recruit and activate downstream partners in intracellular signaling.
Full text:
1
Database:
MEDLINE
Main subject:
Receptor-Interacting Protein Serine-Threonine Kinases
/
Necrosis
Limits:
Humans
Language:
En
Year:
2018
Type:
Article