Effect of low-dose omeprazole on gastric acid secretion in duodenal ulcer patients.
Aliment Pharmacol Ther
; 2(3): 263-8, 1988 Jun.
Article
in En
| MEDLINE
| ID: mdl-2979250
ABSTRACT
The effect of 7 days of oral dosing with 5 mg day-1 and 20 mg day-1 omeprazole on basal and pentagastrin-stimulated gastric acid output was studied in nine duodenal ulcer patients. Basal acid output measured 5-6 h post-dosing was decreased by a mean of 75% on 5 mg omeprazole and by 90% on 20 mg omeprazole (P less than 0.05 and P less than 0.01, respectively). Peak acid output measured 6-7 h post-dosing was decreased by a mean of 75% on 5 mg omeprazole and 97% on 20 mg omeprazole (P less than 0.01 for each). There was a wide interindividual variation in response to the 5 mg dose, with five of the nine patients having more than 90% inhibition of peak acid output, but two patients having less than 40% inhibition. This unpredictable response to daily low-dose omeprazole therapy makes it unsuitable for maintenance treatment.
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Database:
MEDLINE
Main subject:
Omeprazole
/
Duodenal Ulcer
/
Gastric Acid
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Year:
1988
Type:
Article