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Development of autotaxin inhibitors: A series of zinc binding triazoles.
Thomson, Christopher G; Le Grand, Darren; Dowling, Mark; Brocklehurst, Cara E; Chinn, Colin; Elphick, Lucy; Faller, Michael; Freeman, Mark; Furminger, Vikki; Gasser, Cornelia; Hamadi, Ahmed; Hardaker, Elizabeth; Head, Victoria; Hill, Johan C; Janus, Diana I; Pearce, David; Poulaud, Anne-Sophie; Stanley, Emily; Sviridenko, Lilya.
Affiliation
  • Thomson CG; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK. Electronic address: chris.thomson@pharmaron-uk.com.
  • Le Grand D; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Dowling M; Respiratory Disease Area, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Brocklehurst CE; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Fabrikstrasse, CH-4056 Basel, Switzerland.
  • Chinn C; Chemical and Pharmaceutical Profiling, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Elphick L; Respiratory Disease Area, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Faller M; Department of Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Fabrikstrasse, CH-4056 Basel, Switzerland.
  • Freeman M; Respiratory Disease Area, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Furminger V; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Gasser C; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Fabrikstrasse, CH-4056 Basel, Switzerland.
  • Hamadi A; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Hardaker E; Respiratory Disease Area, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Head V; Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Hill JC; Respiratory Disease Area, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Janus DI; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Pearce D; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Poulaud AS; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Stanley E; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
  • Sviridenko L; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Horsham RH12 5AB, UK.
Bioorg Med Chem Lett ; 28(13): 2279-2284, 2018 07 15.
Article in En | MEDLINE | ID: mdl-29798825
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Full text: 1 Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Triazoles / Drug Design / Phosphoric Diester Hydrolases Limits: Animals / Humans / Male Language: En Year: 2018 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Phosphodiesterase Inhibitors / Triazoles / Drug Design / Phosphoric Diester Hydrolases Limits: Animals / Humans / Male Language: En Year: 2018 Type: Article